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Monday, May 18, 2020 | History

2 edition of small conductance swelling-activated chloride channel in primary rat microglia: Biophysical characterization and its contribution to volume regulation and phagocytosis. found in the catalog.

small conductance swelling-activated chloride channel in primary rat microglia: Biophysical characterization and its contribution to volume regulation and phagocytosis.

Guillaume Ducharme

small conductance swelling-activated chloride channel in primary rat microglia: Biophysical characterization and its contribution to volume regulation and phagocytosis.

by Guillaume Ducharme

  • 71 Want to read
  • 16 Currently reading

Published .
Written in English


About the Edition

Microglia are immuno-competent cells of the central nervous system (CNS) that function as macrophages during brain development and pathology. They secrete soluble factors that have neurotoxic and neuroprotective effects. They express ion channels crucial to their function including a swelling-activated chloride channel. Its key biophysical characteristics and some of its physiological functions were investigated. Akin to other swelling-activated conductances, a halide selectivity sequence of I- > Br- > Cl- > F and no time-dependent inactivation at potentials up to 100 mV, even under high extracellular Mg2+, were found. Contrary to the intermediate conductance Iclswell, a small single channel conductance (3 to 5 pS) was found using noise analysis. This suggests that microglial Iclswell is distinct from the Iclswell in other cell types. Drugs that inhibited Iclswell interfered with normosmotic volume regulation and regulatory volume decrease (RVD). Additionally, all Iclswell blockers tested inhibited microglial phagocytosis in a dose-dependent manner.

The Physical Object
Pagination93 leaves.
Number of Pages93
ID Numbers
Open LibraryOL21219177M
ISBN 109780494275016


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Small conductance swelling-activated chloride channel in primary rat microglia: Biophysical characterization and its contribution to volume regulation and phagocytosis by Guillaume Ducharme Download PDF EPUB FB2